TREATMENT OUTCOME AND TOXICITY OF HYPOFRACTIONATED RADIOTHERAPY WITH CONCOMITANT CHEMOTHERAPY VERSUS CONVENTIONAL FRACTIONATED CONCOMITANT CHEMORADIATION IN LOCALLY ADVANCED HEAD-AND-NECK CARCINOMA: A COMPARATIVE STUDY

Objectives: In our study, radiation of a higher dose per fraction (2.75 Gy/fraction, total 55 Gy/20 fractions/4 weeks) with concomitant chemotherapy was compared conventional chemoradiation (2 66 Gy/33 fractions/6 and half weeks, chemotherapy), in patients locally advanced squamous cell carcinomas head neck terms efficacy toxicities. Methods: A 75 registered at the Department Radiotherapy, NRS Medical College Hospital, Kolkata, were allotted two arms chronologically 1:1 ratio. Arm – Patients received hypofractionated radiotherapy, fractions 4 weeks weekly cisplatin (40 mg/m2). B 6½ Results: Both toxicities, hypofractionation arm comparable to arm, no statistically significant difference present between arms. For study complete response 56.6%, partial 36.6%, for control 50% 37.5% (p=0.750). acute toxicities late dysphagia, both almost similar. Conclusion: The regimen associated tolerable satisfactory local control. Considering patient load, overall treatment time, cost hospital stay, this is good option low-resource setup.